Macedonian Journal of Medical Sciences
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Abstract                                                                         [Full-Text PDF] [Macedonian Abstract] [OnlineFirst Full-Text PDF]


Macedonian Journal of Medical Sciences. 2009 Mar 15; 2(1):42-48.


Clinical Science


Prevalence of Aspirin-Induced Asthma in Certain Group of Kosovo Population and its Presentation

Luljeta Neziri Ahmetaj1, Fatime Kokollari2, Violeta Lokaj3

1Allergology and Immunology; 2Dermatology; 3Physiology, Prishtina University Hospital Clinic, Prishtina, Kosovo


Background. Aspirin-induced asthma (AIA) is characterized by onset of asthma attack 30 minutes to 3 hours after ingestion of aspirin or NSAIDs (Non steroid anti-inflammatory drugs). The typical reaction may be accompanied by intense rhinorhea, periorbital edema with conjunctival irritation and facial flushing. Often, at physical examination, nasal polyposis and serum eosinophilia are notable.

Aim: The aim of this study is to identify the behavior of aspirin induced asthma in a certain group of Kosovo population, in terms of age and its presentation.

Material and methods. At the University Hospital Centre in Prishtina, 172 adult patients with asthma were diagnosed, while 16 (9.3 %) of them were with aspirin-induced asthma (f/m=12/4).

Results. The average age was 40.2 years. Nine of them showed triad of symptoms (aspirin-intolerance, asthma, nasal polyposis) while 7 (43.7%) showed tetrad of symptoms (aspirin-intolerance, asthma, nasal polyposis, and sinusitis). Total IgE levels were increased only in 3 patients (18.8%), while eosinophilia was increased only in 8 (50%) of the patients. The skin prick test with standard set of inhalant allergens was positive only in 3 patients (18.8%). There was no correlation between in vitro and in vivo tests.

Conclusion. Since there is no reliable in vitro test for the diagnosis of aspirin sensitivity, definitive diagnosis requires an oral or nasal aspirin challenge, which needs to be performed in a hospital.


Key words: Asthma; Aspirin-induced asthma; Total IgE; Skin prick test; Kosovo.



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