Kalina Gjorgjievska1, Maja Slaninka-Miceska1, Gordana
1Department of Preclinical and Clinical Pharmacology and
Toxicology, Medical Faculty, University “Ss Cyril and Methodius”, Skopje,
Republic of Macedonia; 2Department of Pathology, Medical Faculty,
University “Ss Cyril and Methodius”, Skopje, Republic of Macedonia
Aim: Aliskiren is the first orally active renin inhibitor approved
for treatment of essential hypertension. There are as yet no clinical data
regarding the ability of aliskiren to prevent clinical end-points or reduce
end-organ damage over and above the presumed effects of blood pressure
reduction. The aim of this study was to find out if aliskiren has a
potential to improve renal function and if it has a protective effect on
hypertension target organs (kidney, heart and aorta).
Materials and Methods: The study was conducted on 64 SHR rats (male
and female), 20 weeks old, weighing from 250-300 g. Animals were divided
into 4 groups and treated with aliskiren (100 mg/kg bw/24 h), enalapril (10
mg/kg bw/24 h) and valsartan (10 mg/kg bw/24 h). Effects of investigated
drugs were evaluated by urinalysis and histopathological analysis.
Results: Diuresis was significantly increased in the group of animals
treated with enalapril and valsartan. Effect on diuresis with aliskiren was
mild and statistically insignificant. No significant difference in urine pH
between treated and control group of SHR rats was noted. Albuminuria was
decreased in animals treated with enalapril and valsartan. Aliskiren after
28 days of treatment had a statistically insignificant effect on albuminuria
in SHR rats. Only certain changes of wall thickness of arteries and
arterioles were noted that led to improved perfusion and function of the
kidneys more pronounced in rats treated with valsartan and enalapril.
Effects of aliskiren on target organs were inferior compared to valsartan
Conclusion: In SHR experimental model aliskiren has minor effects on
hypertension target organs when compared to enalapril and valsaratan.
Citation: Gjorgjievska K, Slaninka-Miceska M, Petrusevska G.
Protective Effects of Aliskiren, Enalapril and Valsartan on Hypertension
Target Organs in Spontaneously Hypertensive Rats. Maced J Med Sci. 2011 Jun
15; 4(2):152-157. doi.10.3889/MJMS.1957-5773.2011.0176.
Key words: aliskiren; enalapril; valsartan; SHR; protective effects.
Correspondence: Kalina Gjorgjievska, MD. Department of Preclinical
and Clinical Pharmacology and Toxicology, Medical Faculty, University “Ss
Cyril and Methodius”, Skopje, Republic of Macedonia. E-mail:
Received: 19-Apr-2011; Revised: 2-May-2011; Accepted: 20-May-2011; Online
Copyright: © Gjorgjievska K. This is an open-access article
distributed under the terms of the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any
medium, provided the original author and source are credited.
Competing Interests: The author have declared that no competing