Rangappa Srinath¹, Marikunte Venkataranganna², Janardhan Saravanan³

Aim: The present study was aimed to evaluate some newly synthesized thieno – [2, 3-d] - pyrimidin-4-(3H)-ones namely SR-C1 to SR-C12 for their anti-hyperlipidemic activity.

Materials and Methods: Anti-hyperlipidemic activity was evaluated using Triton 1339-induced hyperlipedemia in rats as an experimental model. Plasma triglycerides, total cholesterol, HDL-C, LDL-C, atherogenic index (AI) and LDL-C/HDL-C ratio were determined to assess the anti-hyperlipidemic activity.

Results: SR-C1,SR-C4, SR-C5, SR-C6, SR-C7, SR-C11 and SR-C12 have shown significant anti-hyperlipidemic activity by decreasing the total cholesterol and triglyceride, LDL-cholesterol, atherogenic index and LDL/HDL ratio (p < 0.001) and by increasing the HDL-Cholesterol (p < 0.001).

Conclusion: The findings of the present study clearly demonstrates that methyl, methoxy, chloro, dimethylamino, dimethoxy and trimethoxy functional groups possess cholesterol-suppressive capacities and has an ability to attenuate the accelerated development of atherosclerosis in hypercholesterolemic models. However, hydroxyl and nitro derivatives did not show any hypolipidemic activity.

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Citation: Srinath R, Venkataranganna M, Saravanan J. Anti-hyperlipidemic Activity of Thieno – [2, 3-d] - Pyrimidin-4-(3H)-ones. Maced J Med Sci. 2011 Dec 15; 4(4):358-366. http://dx.doi.org/10.3889/MJMS.1957-5773.2011.0189.
Key words: Thieno – [2, 3-D] - pyrimidin-4-(3H)-ones; Hyperlipidemic; Hypotriglyceridaemia; Atherogenic index.
Correspondence: Mr. Rangappa Srinath. PES College of Pharmacy, Pharmacology, 50 feet road, Hanumanthanagar, Bangalore, Bangaluru, Karnataka 560050, India. Phone: 9448710137. E-Mail: srinathrangappa@rediffmail.com
Received: 02-Jul-2011; Revised: 28-Aug-2011; Accepted: 29-Aug-2011; Online first: 06-Oct-2011
Copyright: © 2011 Srinath R. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Competing Interests: The authors have declared that no competing interests exist.
 

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