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Macedonian Journal of Medical Sciences. 2011 Dec
15;
4(4):411-418.
http://dx.doi.org/10.3889/MJMS.1957-5773.2011.0196
Public Health
Cadaver Transplantation in Balkans: Mission Possible?
Vladimir Chadikovski, Aco Dimov, Mile Petrovski, Risto Simeonov, Branka
Petrovska
University Clinic for Pediatric Surgery, Faculty of Medicine, Ss Cyril
and Methodius University, Skopje, Republic of Macedonia
Background: Donation of organs is on a very low level and due to its
specific nature is a very sensitive topic, especially in the post – conflict
and multinational country like Republic of Macedonia.
Aim: The NGO National Transplant Foundation has conducted a study in
order to gain understanding about factors that drive awareness, attitudes
towards donation of organs and willingness to participate.
Material and Methods: The study was conducted on a representative sample of
1000 respondents using standardized questionnaire via face to face method in
September 2009. Answers on all questions were cross tabulated in order to
detect patterns. Factor analysis and cluster analysis were used for
identification of different segments of respondents.
Results: The results revealed that majority of population in
Macedonia is familiar with the term transplantation, but there is a very low
awareness that a specific law for organ donation exists. Segmentation
analysis identified several groups of responders: apostles (23%),
mercenaries (11%), escapists (26%), neutral (13%) and hostages (28%). More
precisely, apostles are people who perceive transplantation or donations of
organ as human act and who already participate in some humanitarian activity
like blood donation. The participants were divided upon their opinion
whether they would donate their organs after death. The reasons for this are
found in negative attitude towards donation and low level of trust in
institutions.
Conclusion: The survey clearly indicates that there is a need for
informing the population about the law and the process of donation of organs
in Macedonia. Inclusion of certain benefits like health or social insurance
will stimulate the process of donation of organs. Another important output
is that mercenaries and escapists are groups which should be targeted, while
apostles and neutral could be used as promoters of the idea.
...................
Citation: Chadikovski V, Dimov A, Petrovski M, Simeonov R, Petrovska
B. Cadaver Transplantation in Balkans: Mission Possible? Maced J Med Sci.
2011 Dec 15; 4(4):411-416.
http://dx.doi.org/10.3889/MJMS.1957-5773.2011.0196.
Key words: Cadaveric transplantation; interview; factor analysis;
cluster analysis Balkans; Republic of Macedonia.
Correspondence: Vladimir Chadikovski, MD. University Clinic for
Pediatric Surgery, Faculty of Medicine, Ss Cyril and Methodius University,
Skopje, Republic of Macedonia. E-mail: vcadik73@yahoo.com;
cadikovski@yahoo.com
Received: 17-Aug-2010; Revised: 20-Oct-2011; Accepted: 25-Oct-2011; Online
first: 28-Nov-2011
Copyright: © 2011 Chadikovski V. This is an open access article
distributed under the terms of the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any
medium, provided the original author and source are credited.
Competing Interests: The authors have declared that no competing
interests exist.

At present, In Republic of Macedonia routinely are performed transplantation
of kidneys (around 15 per year) and bone marrow around 50 per year), while
introduction of liver transplantation in children is in progress. The lack
of cadaveric organs for transplantation motivates some Macedonian patients,
as well as patients from other Balkan,countries to buy a kidney for example
from developing countries [1]. There have been attempts to compare combined
data from the national renal registries of Balkan countries with combined
data from renal registries of the Western and Northern European Countries
and regions contributing the ERA-EDTA Registry [2]. However, a lot of
efforts remain to be done in order The Balkans and Republic of Macedonia as
part of it to meet the criteria regarding transplantation (especially
cadavaeric) accepted in the developed world.
There is a very low level of awareness regarding donation of organs in
Republic of Macedonia. This is a very sensitive topic, especially in the
post–conflict and multinational country like Republic of Macedonia. There
are different factors that are related to awareness, attitudes towards
donation of organs and willingness to participate and therefore this
deserves further exploration. So far, there are no data regarding
transplantation and this is the first survey of this kind in Republic of
Macedonia.
Regarding the legal framework, there is a law concerning conditions for
taking, exchanging, passing on, and transplanting the human body parts for
the purpose of patient treatment, published in Official Gazette of the
Republic of Macedonia nr.30/95 from 14.06.1995 [3]. In this context, (part
of this law) there are clinical rules set which apply to further examination
and determination of death in person from which body parts can be taken for
medical treatment. This law was later amended with another law (Law on
changes and amendments to the law concerning conditions for taking,
exchanging, passing on, and transplanting the human body parts for the
purpose of patient treatment) which was published in Official Gazette of RM
no. 139 of 04.11.2008 [4].
The mission of National Transplantation Foundation (NTF) is to raise
awareness of the need for organ donation and transplantation as a critical
method of improving patients’ quality of life. The NTF is also aimed at
encouraging application of high medical, ethical and legal standards
surrounding transplantation and establish a synergy between healthcare
professionals and society at large.
The objectives of the foundation are: to raise donation and transplantation
awareness through education of healthcare professionals and the general
public; to support research in the area of organ transplantation; to support
families with members in need of transplantation or those that have already
donated/received an organ transplant; to help in providing technical
support, instruments and equipment required for transplantation; and to help
develop, adjust and implement the legal and ethical framework for
transplantation in Macedonia.
The aim of this study was to conduct analyze and understand the factors that
drive awareness, attitudes towards donation of organs and willingness to
participate in such a procedure. in the Republic of Macedonia through a
survey.

Study Design
This is a descriptive study with objective to describe and measure the
phenomena of interest in a certain point of time. More precisely, it is a
cross-sectional study known as “snap-shots” of the population because of the
one-time measurement [5].
Study population
The population of interest for this study was total population (15+) of the
Republic of Macedonia. The sample is a tool in order to infer something
about the population [6]. Therefore, sample of 1000 respondents were
included in the research. Participants were recruited on a voluntary basis,
based on the method “start and step”. The interviewer receives sampling
point and conducts the interview with members of households which live on
the chosen street. The interviewer starts from the n-house specified and
visits every n-house according to the step. The survey was conducted in the
homes of the respondents via face to face method. The sample is considered
representative of the population. The questionnaire was administered by
interviewers from GfK Skopje which were trained for this purpose.
Statistical analysis
Answers on all questions were cross tabulated in order to detect patterns.
Also, factor analysis and cluster analysis were used for identification of
different segments of people. Firstly, factor analysis was performed on the
results from statements that describe attitudes towards donation of organs.
Factor analysis is used for searching underlying factors within the data
set. Out of the defined factors, several groups mostly saturated with
specific factors were indentified through a cluster analysis. The basic
purpose of cluster analysis is to segment objects into groups that objects
within each group are similar to one another on a variety of characteristics
[7].

The classification of participants in the survey is based on the guidlelines
accepted on a creative workshop conducted with GfK members and members of
National Foundation for Transplantation. The names are given only based on
personality patterns. Recruitment could be conducted with characteristics
which match the specific profile. Description of profiles (extracted with
cluster analysis) – factors of lifestyle and value system is shown in Table
1.
Table 1: Description of profiles (extracted with cluster analysis) – factors
of lifestyle and value system.

The bigest part of profiles in our study were hostages and escapists with
28% and 26%, respectively, followed with apostles (23%), neutral (13%), and
mercenaries (11%).
Participation in any kind of humanitarian activity is shown in Fig. 1. Three
percent (3%) of population said that regularly participate in humanitarian
actions and 43% that have participated few times. Neutral and Apostles have
highest percentage of participation in humanitarian actions. Most of
participants donate blood (56%), about one third donate clothes (24%), the
rest of particpiants donate money (12%), and other donations.

Figure 1: Have you ever participate in any kind of humanitarian activity?
The gender, age, education and nationalitiy of investigated sample according
the profiles is shown in Fig. 2. Half of the participants are females (53%)
with bigest percentage (70%) in apostles profile, in contrast to males with
biggest percentage (73%) in mercenaries profile. The bigest percentage of
all profiles belongs to the age 20-34 years. Most of the participants
finished high school (58%), 78% were Macedonians, and 20% Albanians (Fig.
2).

Figure 2: Sample description.
High percentage of the Macedonian citizens know what the word
“transplantation” means: high 89% of them describe it as transplantation of
healthy organs from one person to another. Surprisingly – 6% of the
population have had need of transplantation, the highest percentage needed
kidney transplantation. Answers to the question “Have you or some member of
your family ever had the need of transplantation?” show that 69% need kidney
transplantation, 8% need bone marrow transplantation, 6% need lung and/or
heart transplantaton and the rest of praticipants have had need of blood,
cornea or somthing else. Two percent of the population have had experience
with organs donation – this 2% means that maximum 2.800 people experienced
what transplantation means (N/A data means don’t know or no answer) but
still these people could be used as testimonials (Fig. 3).

Figure 3: Have you or some member of your family ever had the need of
transplantation?
Almost half of the population knows that transplantations are being made in
Macedonia. However, low awareness of the existence of the Law for
Transplantation in Macedonia was noted. People from segments Escapist and
Hostages are informed better than people from other segments (Fig. 4).

Figure 4: Do you know, if there is any law for organ transplantation in
Republic of Macedonia?
Most of the participants would claim donation of their organs (22%
certainly, and 40% probably) in case of death, of which Apostles are the
most certain (31%). Mercenaries and Hostages are at least ready for
voluntary sign of this document (Fig. 5).

Figure 5: Would you agree to sign for donation of your organs, in case of
death?
As reasons for not signing this kind of document are verbalized: morbid to
think about death while you’re alive (46), contrary to common views on life
and death (20%) and no trust in Institutions (22%) (Fig. 6).

Figure 6: What are the reasons because of you wouldn’t sign for donation of
your organs?
All segments are ready to sign this documents no matter to whom the organs
will be donated except Escapists segment who will sign only for donating the
organs to closely related people (Fig. 7).

Figure 7: Would you sign this statement no matter to whom your organs will
be donated or you will have particular conditions?
Expectations of award significantly influence readiness for donation among
participants of the survey. Mercenaries and Escapists express opinion that
donating organs should be awarded by State Institutions. Awards should be:
money, health insurance benefits and social insurance benefits. As a
strongest motive for stimulation of donating organs is material compensation
– money, exception of tax payment and other health or social insurance
benefits (Fig. 8).

Figure 8: Do you think that donating organs should be awarded by some
institutions?
Acceptance of organs in case of a need is pretty high but still seems
connected with readiness of donating. The most ready to accept an organ from
unknown donor are individuals in segments Neutrals and Apostles who are in
the same time highly ready to donate organs to unknown person in need. The
strongest motive for rejection of transplantation is belief in fate or
belief that natural death is most appropriate end.
Making decision about donating organs for someone close is more difficult
than decision about signing the document for him/her self. Significantly
lower percent of respondents express readiness for signing the documents if
some close to them is in situation to be potential donor (cerebral death).
This decision could be made easier with support of other members of the
family. In case of need of an organ from some member of the family, the
respondent’s readiness for donating is significantly higher but still
stratified in three segments: Mercenaries, Escapists and Hostages
uncertainty is high. As main de-motivator (or uncertainty) are mentioned
health problems, fear for adverse effects on their health and life in
general (Fig.9).

Figure 9: What would be the strongest motive for people to decide to donate
organs?
According to the general opinion, reasons for low readiness for donating
organs are: low trust in Institutions and low awareness for this issue.
Apostles are people who perceive transplantation or donation of organ as a
human act – (significantly higher percentage than in other segments are
ready to donate organs). Mercenaries and Escapist are segments who are
pretty suspicious about the procedure, or they think that the
transplantation/donation of organs is vulnerable to corruption and
mismanagement. Opposite of his/her religion is characterization of only 36%
of hostages (which is surprisingly low percentage for people who feel that
religious barriers are real). One of the possible explanation for misuse of
religion is no other argument to avoid discussion on this topic (Fig. 10).

Figure 10: What are the reasons people would not decide to donate organs?

High percentage of the Macedonian citizens know what the word
“transplantation” means: high 89% of them describe it as transplantation of
healthy organs from one person to another. Surprisingly 6% of the population
have need for transplantation. The highest percentage has need for kidney
transplantation. 2% of the population have had experience with organs
donation – this 2% means that max 2.800 people experienced what
transplantation means (N/A data does this experience was positive or
negative) but still these people could be used as testimonials.
Almost half of the population knows that transplantations are being made in
Macedonia. The awareness about the Law for Transplantation in Macedonia have
shown that: people from segments Escapist and Hostages are informed better
than other segments; apostles are people who perceive transplantation or
donation of organ as a Human act – (significantly higher percentage than in
other segments); Mercenaries and Escapist are segments who express opinion
that transplantation/donation of organs is according to their opinion in
higher % than other segments but unfortunately they are pretty suspicious
about the procedure or more precisely they think that the
transplantation/donation of organs is vulnerable to corruption and
mismanagement; opposite of my religion is characterization of only 36% of
hostages (which is surprisingly low % of people who feel that religious
barriers are real) one of the possible explanation for misuse of religion is
no other argument to avoid discussion on this topic.
Twenty two percent of total population are ready to sign statements (in case
of death) their organs to be donated, the most ready for this act is
Apostles segment, Mercenaries and Hostages are at least ready for voluntary
sign of this document.
As reasons for not signing this kind of document are verbalized: Morbid to
think about death while you’re alive; contrary to common views on life and
death and no trust in Institutions. All segments are ready to sign this
documents no matter to whom the organs will be donated except Escapists
segment they will sign only for donating the organs to close people.
Making decision about donating organs of some close is more difficult than
decision about signing the document for self. Significantly lower % of
respondents express readiness for signing the documents if some close to
them is in case as potential donor (cerebral death). This decision could be
made easier with support of other members of the family.
In case of need of organ from some member of family, the respondent’s
readiness for donating is significantly higher but still in three segments:
Mercenaries, Escapists and Hostages uncertainty is high. As main
de-motivator (or uncertainty) are mentioned health problems, fear for
effects on health and life in general.
Acceptance of organs in case of need is pretty high but still seems
connected with readiness of donating: the most ready to accept organ from
unknown donor are segments Neutral and Apostles who are in the same time
highly ready to donate organs to unknown person; the strongest motive for
rejection of transplantation as a solution is fate or opinion that natural
death is most appropriate end.
Expectations of award significantly influence readiness for donating.
Mercenaries and Escapists express opinion (in higher % than Apostles and
Neutral) that donating organs should be awarded by State Institutions,
awards should be: money, health insurance benefits and social insurance
benefits. As a strongest motive for stimulation of donating is material
compensation – money, exception of tax payment and other health or social
insurance benefits.
According to general opinion, reasons of low readiness for donating organs
are: Low trust in Institutions and low awareness for this issue. 3% of
population said that regularly participate in humanitarian actions and 43%
that have participated few times. Neutral and Apostles have highest % of
participation in humanitarian actions.
The conclusion clearly indicates that there is a need for informing the
population about the law and the process of donation of organs in Macedonia.
This implies need for further marketing activities in promoting the idea.
Potential target groups are: Mercenaries and Escapists. Apostles and Neutral
could be used as Promoters of ideas. As a promotions could be organized
events (similar to those in Croatia and Slovenia) with active participation
of doctors, professional soldiers or representatives from army;
humanitarians, professors (educational system) and foreign factor in
Macedonia .
Communication should be based on: raising the trust in Institutions involved
in process of transplantation; minimization of fear for negative influence
on health and life (security of data for these people who will sign this
document); and act of humanism, altruism.
Inclusion of some benefits like health or social insurance will stimulate
the process of donation of organs. Some material benefits (health of social
insurance) should be communicated (for all profiles).
Support from abroad should also be accented – NFT as a part of
Eurotransplant.

The research was conducted by GfK Skopje and National Foundation for
Transplantation of Republic of Macedonia. The author would like to
acknowledge assistance provided in the preparation of this study to GfK
Skopje.

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